10 Most Shocking Celeb Weight Changes Many of us try to lose weight for our health and wellness. A few of us try to gain weight, for the same cause. But movie stars frequently have to significantly change their bodies based on the roles they’re given. If you are on Twitter, you may already know that 50 Cent dropped from 214 to a scrawny 160 to look sickly for his role in ‘Things Fall Apart. He regularly posted twitpics of himself getting thinner and thinner. And did you know that Renee Zellweger gained nearly 30 pounds to enjoy the title part in ‘Bridget Jones’s Diary.’ And then there’s Christian Bale, who lost 63 pounds to play the business lead in ‘The Machinist.’ See 10 many shocking celebrity weight adjustments..We chose not to use a sham treatment, provided the imposed risk to the control group without potential advantage.18-20 Additional details about the methodology are given in the Supplementary Appendix, available with the full text of this article at NEJM.org. The scholarly study was conducted relative to the protocol, which is available at NEJM also.org. Outcome Measures The coprimary effectiveness end points were the % change in the FEV1 and range on the 6-minute walk test in the EBV group, as compared with the control group, at 6 months after randomization.